Head and neck cancers include cancers in the larynx, throat, lips, mouth, nose, and salivary glands. Head and neck cancer is the sixth most common malignancy worldwide, accounting for approximately 6% of all cancer cases, and is responsible for an estimated 1% to 2% of all cancer deaths. An estimated 650,000 cases of head and neck cancer are diagnosed annually worldwide, including approximately 50,000 cases in the United States. Tobacco use, heavy alcohol use, and infection with human papillomavirus (HPV) increase the risk of head and neck cancers1. Although five-year overall survival (OS) is good for patients diagnosed with localized (83.7%) or locoregionally advanced (64.2%) squamous cell carcinoma of the head and neck (SCCHN), the cancer often recurs distantly. Recurrent or de novo metastatic SCCHN is virtually incurable and the five-year survival is 38.5%2. Extending patients’ survival is, therefore, an important treatment goal.